TBL1XR1

TBL1XR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LG9
Identifiers
Aliases	TBL1XR1, C21, DC42, IRA1, TBLR1, MRD41, transducin (beta)-like 1 X-linked receptor 1, transducin beta like 1 X-linked receptor 1, TBL1X receptor 1
External IDs	OMIM: 608628; MGI: 2441730; HomoloGene: 69382; GeneCards: TBL1XR1; OMA:TBL1XR1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	177,228,000 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	22,270,758 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; nipple; ; tibia; ; corpus callosum; ; lactiferous duct; ; visceral pleura; ; Brodmann area 23; ; parietal pleura; ; germinal epithelium; ; pylorus;
	Top expressed in
	granulocyte; ; blood; ; zygote; ; calvaria; ; tibiofemoral joint; ; ankle; ; cumulus cell; ; extensor digitorum longus muscle; ; thymus; ; lymph node;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; beta-catenin binding; transcription corepressor activity; protein N-terminus binding; histone binding; protein binding;
Cellular component	histone deacetylase complex; transcription repressor complex; nucleoplasm; spindle microtubule; nucleus; mitotic spindle;
Biological process	fat pad development; response to dietary excess; regulation of transcription, DNA-templated; multicellular organism growth; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; lipid catabolic process; regulation of triglyceride metabolic process; white fat cell differentiation; regulation of gene expression; adipose tissue development; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of lipid metabolic process; positive regulation of canonical Wnt signaling pathway; chromatin organization; blastocyst hatching; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	79718
	81004
	ENSG00000177565
	ENSMUSG00000027630
	Q9BZK7
	Q8BHJ5
NM_024665; NM_001321193; NM_001321194; NM_001321195; NM_001374327;
	NM_001374328; NM_001374329; NM_001374330
	NM_030732
NP_001308122; NP_001308123; NP_001308124; NP_078941; NP_001361256;
	NP_001361257; NP_001361258; NP_001361259
	NP_109657
	Wikidata
View/Edit Human	View/Edit Mouse

F-box-like/WD repeat-containing protein TBL1XR1 is a protein that in humans is encoded by the TBL1XR1 gene. The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins that appear to have a regulatory function. It is believed that the WD40 repeats mediate protein–protein interactions, and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.