TBR1

TBR1
Identifiers
Aliases	TBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 1
External IDs	OMIM: 604616; MGI: 107404; HomoloGene: 4807; GeneCards: TBR1; OMA:TBR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	161,425,870 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	61,644,458 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Brodmann area 10; ; frontal pole; ; Brodmann area 9; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; postcentral gyrus; ; superior frontal gyrus; ; testicle;
	Top expressed in
	cingulate gyrus; ; perirhinal cortex; ; piriform cortex; ; primary motor cortex; ; entorhinal cortex; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; CA3 field;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein kinase binding; protein binding; identical protein binding;
Cellular component	nucleus;
Biological process	commitment of neuronal cell to specific neuron type in forebrain; regulation of gene expression; regulation of axon guidance; brain development; hindbrain development; regulation of transcription, DNA-templated; amygdala development; regulation of neuron projection development; transcription, DNA-templated; specification of animal organ identity; positive regulation of transcription by RNA polymerase II; conditioned taste aversion; neuron differentiation; cerebral cortex development;
	Sources:Amigo / QuickGO
Orthologs
	10716
	21375
	ENSG00000136535
	ENSMUSG00000035033
	Q16650
	Q64336
	NM_006593
	NM_009322
	NP_006584
	NP_033348
	Wikidata
View/Edit Human	View/Edit Mouse

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the TBR1 subfamily include EOMES and TBX21. TBR1 is involved in the differentiation and migration of neurons and is required for normal brain development. TBR1 interacts with various genes and proteins in order to regulate cortical development, specifically within layer VI of the developing six-layered human cortex. Studies show that TBR1 may play a role in major neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and autism spectrum disorder (ASD).