TBRG4

TBRG4
Identifiers
Aliases	TBRG4, CPR2, FASTKD4, transforming growth factor beta regulator 4
External IDs	OMIM: 611325; MGI: 1100868; HomoloGene: 31259; GeneCards: TBRG4; OMA:TBRG4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	45,112,047 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,576,067 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; apex of heart; ; granulocyte; ; gastrocnemius muscle; ; rectum; ; muscle of thigh; ; skin of leg; ; right ovary; ; body of stomach; ; minor salivary glands;
	Top expressed in
	epiblast; ; primitive streak; ; yolk sac; ; tail of embryo; ; internal carotid artery; ; granulocyte; ; muscle of thigh; ; hair follicle; ; endothelial cell of lymphatic vessel; ; condyle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; protein binding; RNA binding;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	cellular respiration; protein phosphorylation; positive regulation of cell population proliferation; mRNA metabolic process; regulation of mitochondrial mRNA stability; mitochondrial mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	9238
	21379
	ENSG00000136270
	ENSMUSG00000000384
	Q969Z0
	Q91YM4
	NM_199122; NM_001261834; NM_004749; NM_030900
NM_001130457; NM_134011; NM_001362713; NM_001362714; NM_001362715;
	NM_001362716
	NP_001248763; NP_004740; NP_112162; NP_954573
NP_001123929; NP_598772; NP_001349642; NP_001349643; NP_001349644;
	NP_001349645
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor beta regulator 4 (TBRG4), also known as cell cycle progression restoration protein 2 (CPR2) and FAST kinase domain-containing protein 4 (FASTKD4), is a protein that in humans is encoded by the TBRG4 gene on chromosome 7. This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress and cell cycle progression. TBRG4 is involved in cell proliferation in hematopoiesis and multiple myeloma.