TCEA1

TCEA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFI, 3NDQ, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8, 5IYC
Identifiers
Aliases	TCEA1, GTF2S, SII, TCEA, TF2S, TFIIS, transcription elongation factor A1
External IDs	OMIM: 601425; MGI: 1196624; HomoloGene: 55984; GeneCards: TCEA1; OMA:TCEA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	54,022,456 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	4,968,132 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; Achilles tendon; ; optic nerve; ; caput epididymis; ; cartilage tissue; ; tail of epididymis; ; corpus epididymis; ; skin of thigh; ; parotid gland; ; lactiferous duct;
	Top expressed in
	zygote; ; fetal liver hematopoietic progenitor cell; ; tail of embryo; ; secondary oocyte; ; medial ganglionic eminence; ; parotid gland; ; lacrimal gland; ; hand; ; calvaria; ; human fetus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; protein binding; metal ion binding; nucleic acid binding;
Cellular component	nucleolus; nucleus; nucleoplasm; transcription factor TFIID complex;
Biological process	transcription elongation from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of exoribonuclease activity; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6917
	21399
	ENSG00000187735
	ENSMUSG00000033813
	P23193
	P10711
	NM_006756; NM_201437
	NM_001159750; NM_001159751; NM_011541
	NP_006747; NP_958845
	NP_001153222; NP_001153223; NP_035671
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene.

In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes possible again. It is also found in the eukaryotic transcription preinitiation complex. A homolog in archaea performs the same main task, while bacteria use the non-homologous Gre.