TCF21 (gene)

TCF21
Identifiers
Aliases	TCF21, POD1, bHLHa23, transcription factor 21
External IDs	OMIM: 603306; MGI: 1202715; HomoloGene: 2414; GeneCards: TCF21; OMA:TCF21 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	133,895,553 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	22,696,073 bp
RNA expression pattern
	Top expressed in
	gonad; ; right lung; ; upper lobe of left lung; ; left ovary; ; right ovary; ; lower lobe of lung; ; glomerulus; ; spleen; ; metanephric glomerulus; ; right auricle of heart;
	Top expressed in
	left lung lobe; ; vas deferens; ; Gonadal ridge; ; efferent ductule; ; right lung lobe; ; migratory enteric neural crest cell; ; stroma of kidney; ; septum transversum; ; atrium; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; bHLH transcription factor binding; E-box binding; androgen receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	roof of mouth development; ureteric bud development; regulation of transcription, DNA-templated; epithelial cell differentiation; lung morphogenesis; diaphragm development; kidney development; metanephric mesenchymal cell differentiation; negative regulation of androgen receptor signaling pathway; bronchiole development; Sertoli cell differentiation; glomerulus development; sex differentiation; negative regulation of transcription by RNA polymerase II; spleen development; transcription by RNA polymerase II; morphogenesis of a branching structure; transcription, DNA-templated; reproductive structure development; metanephric glomerular capillary formation; branching involved in ureteric bud morphogenesis; vasculature development; sex-determination system; respiratory system development; embryonic digestive tract morphogenesis; animal organ morphogenesis; lung alveolus development; lung vasculature development; branchiomeric skeletal muscle development; positive regulation of transcription by RNA polymerase II; gland development;
	Sources:Amigo / QuickGO
Orthologs
	6943
	21412
	ENSG00000118526
	ENSMUSG00000045680
	O43680
	O35437
	NM_198392; NM_003206
	NM_011545
	NP_003197; NP_938206
	NP_035675
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 21 (TCF21), also known as pod-1, capsuling, or epicardin, is a protein that in humans is encoded by the TCF21 gene on chromosome 6. It is ubiquitously expressed in many tissues and cell types and highly significantly expressed in lung and placenta. TCF21 is crucial for the development of a number of cell types during embryogenesis of the heart, lung, kidney, and spleen. TCF21 is also deregulated in several types of cancers, and thus known to function as a tumor suppressor. The TCF21 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.