TCF7L2

TCF7L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GL7, 1JDH, 1JPW
Identifiers
Aliases	TCF7L2, TCF-4, TCF4, transcription factor 7 like 2
External IDs	OMIM: 602228; MGI: 1202879; HomoloGene: 7564; GeneCards: TCF7L2; OMA:TCF7L2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	113,167,678 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	55,922,086 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; endothelial cell; ; pancreatic ductal cell; ; hair follicle; ; decidua; ; epithelium of lactiferous gland; ; lactiferous duct; ; tibia; ; visceral pleura; ; germinal epithelium;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; habenula; ; lateral geniculate nucleus; ; inferior colliculi; ; ascending aorta; ; aortic valve; ; internal carotid artery; ; external carotid artery; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; beta-catenin binding; gamma-catenin binding; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; armadillo repeat domain binding; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding;
Cellular component	beta-catenin-TCF7L2 complex; PML body; nucleoplasm; protein-DNA complex; nucleus; transcription regulator complex;
Biological process	positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of protein kinase B signaling; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; response to glucose; Wnt signaling pathway; regulation of smooth muscle cell proliferation; negative regulation of DNA-binding transcription factor activity; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; transcription, DNA-templated; positive regulation of protein export from nucleus; maintenance of DNA repeat elements; blood vessel development; myoblast fate commitment; canonical Wnt signaling pathway; pancreas development; positive regulation of protein binding; regulation of hormone metabolic process; cell population proliferation; negative regulation of transcription, DNA-templated; fat cell differentiation; negative regulation of canonical Wnt signaling pathway; beta-catenin-TCF complex assembly; Wnt signaling pathway, calcium modulating pathway; positive regulation of insulin secretion; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; negative regulation of type B pancreatic cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6934
	21416
	ENSG00000148737
	ENSMUSG00000024985
	Q9NQB0
	Q924A0
NM_001146274; NM_001146283; NM_001146284; NM_001146285; NM_001146286;
	NM_001198525; NM_001198526; NM_001198527; NM_001198528; NM_001198529; NM_001198530; NM_001198531; NM_030756; NM_001349870; NM_001349871; NM_001363501; NM_001367943
NM_001142918; NM_001142919; NM_001142920; NM_001142921; NM_001142922;
	NM_001142923; NM_001142924; NM_009333; NM_001331135; NM_001331136; NM_001331137; NM_001331138; NM_001331139; NM_001331140; NM_001331141; NM_001331142; NM_001331143; NM_001331144; NM_001331145; NM_001331146; NM_001331147; NM_001331148; NM_001331149; NM_001331150
NP_001139746; NP_001139755; NP_001139756; NP_001139757; NP_001139758;
	NP_001185454; NP_001185455; NP_001185456; NP_001185457; NP_001185458; NP_001185459; NP_001185460; NP_110383; NP_001336799; NP_001336800; NP_001350430; NP_001354872; NP_001139757.1
NP_001136390; NP_001136391; NP_001136392; NP_001136393; NP_001136394;
	NP_001136395; NP_001136396; NP_001318064; NP_001318065; NP_001318066; NP_001318067; NP_001318068; NP_001318069; NP_001318070; NP_001318071; NP_001318072; NP_001318073; NP_001318074; NP_001318075; NP_001318076; NP_001318077; NP_001318078; NP_001318079; NP_033359
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence several biological pathways, including the Wnt signalling pathway.

Single-nucleotide polymorphisms (SNPs) in this gene are especially known to be linked to higher risk to develop type 2 diabetes, gestational diabetes, multiple neurodevelopmental disorders including schizophrenia and autism spectrum disorder, as well as other diseases. The SNP rs7903146, within the TCF7L2 gene, is, to date, the most significant genetic marker associated with type 2 diabetes risk.