TEC (gene)

TEC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LUL
Identifiers
Aliases	TEC, PSCTK4, tec protein tyrosine kinase
External IDs	OMIM: 600583; MGI: 98662; HomoloGene: 1302; GeneCards: TEC; OMA:TEC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	48,269,838 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	73,025,826 bp
RNA expression pattern
	Top expressed in
	gonad; ; bone marrow cells; ; testicle; ; skin of leg; ; skin of abdomen; ; monocyte; ; right uterine tube; ; rectum; ; right lung; ; right adrenal cortex;
	Top expressed in
	sciatic nerve; ; granulocyte; ; spleen; ; left lobe of liver; ; mesenteric lymph nodes; ; blood; ; proximal tubule; ; bone marrow; ; right kidney; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; phospholipid binding; ATP binding; lipid binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; plasma membrane;
Biological process	B cell receptor signaling pathway; cell differentiation; intracellular signal transduction; adaptive immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; Fc-epsilon receptor signaling pathway; protein phosphorylation; regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; regulation of platelet activation; innate immune response; tissue regeneration; cytokine-mediated signaling pathway; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7006
	21682
	ENSG00000135605
	ENSMUSG00000029217
	P42680
	P24604
	NM_003215
	NM_001113460; NM_001113461; NM_001113464; NM_013689
	NP_003206
	NP_001106931; NP_001106932; NP_001106935; NP_038717
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. Tec kinase is expressed in hematopoietic, liver, and kidney cells and plays an important role in T-helper cell processes. Tec kinase is the name-giving member of the Tec kinase family, a family of non-receptor protein-tyrosine kinases.