TERF2IP

TERF2IP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FEX, 3K6G, 4RQI
Identifiers
Aliases	TERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDs	OMIM: 605061; MGI: 1929871; HomoloGene: 10357; GeneCards: TERF2IP; OMA:TERF2IP - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,761,872 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,747,160 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; pars compacta; ; pars reticulata; ; superior vestibular nucleus; ; Pons; ; internal globus pallidus; ; lateral nuclear group of thalamus; ; Brodmann area 9; ; superior frontal gyrus;
	Top expressed in
	ventromedial nucleus; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; lumbar subsegment of spinal cord; ; ventral tegmental area; ; arcuate nucleus; ; dorsal tegmental nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; telomeric DNA binding; protein binding; G-rich strand telomeric DNA binding; phosphatase binding;
Cellular component	nuclear telomere cap complex; nuclear envelope; chromosome; shelterin complex; telomere; nuclear chromosome; Mre11 complex; nucleus; nucleoplasm; cytosol; nuclear body; cytoplasm;
Biological process	negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; protection from non-homologous end joining at telomere; regulation of double-strand break repair via homologous recombination; transcription, DNA-templated; positive regulation of peptidyl-serine phosphorylation; protein localization to chromosome, telomeric region; positive regulation of protein acetylation; telomere maintenance via telomere lengthening; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; telomere maintenance; telomere capping; negative regulation of protein phosphorylation; regulation of transcription, DNA-templated; regulation of telomere maintenance; negative regulation of telomere maintenance; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	54386
	57321
	ENSG00000166848
	ENSMUSG00000033430
	Q9NYB0
	Q91VL8
	NM_018975
	NM_020584
	NP_061848
	NP_065609
	Wikidata
View/Edit Human	View/Edit Mouse

Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene.