Testin

TES
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IYB, 2XQN
Identifiers
Aliases	TES, TESS, TESS-2, testin LIM domain protein
External IDs	OMIM: 606085; MGI: 105081; HomoloGene: 41051; GeneCards: TES; OMA:TES - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	116,258,783 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	17,105,827 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; seminal vesicula; ; saphenous vein; ; gastric mucosa; ; superficial temporal artery; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; nipple; ; myometrium; ; smooth muscle tissue;
	Top expressed in
	retinal pigment epithelium; ; pyloric antrum; ; left colon; ; spermatid; ; seminiferous tubule; ; genital tubercle; ; granulocyte; ; endothelial cell of lymphatic vessel; ; medullary collecting duct; ; gastric mucosa;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; RNA binding; cadherin binding;
Cellular component	cell junction; plasma membrane; nucleus; focal adhesion; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of cell population proliferation; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	26136
	21753
	ENSG00000135269
	ENSMUSG00000029552
	Q9UGI8
	P47226
	NM_015641; NM_152829
	NM_011570; NM_207176
	NP_056456; NP_690042
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Testin (also known as TESS) is a protein that in humans is encoded by the TES gene located on chromosome 7. TES is a 47 kDa protein composed of 421 amino acids found at focal adhesions and is thought to have a role in regulation of cell motility. In addition to this, TES functions as a tumour suppressor. The TES gene is located within a fragile region of chromosome 7, and the promoter elements of the TES gene have been shown to be susceptible to methylation – this prevents the expression of the TES protein. TES came to greater prominence towards the end of 2007 as a potential mechanism for its tumour suppressor function was published.