Tet methylcytosine dioxygenase 2

TET2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NM6, 5DEU, 5D9Y
Identifiers
Aliases	TET2, KIAA1546, MDS, tet methylcytosine dioxygenase 2, Tet methylcytosine dioxygenase 2, IMD75
External IDs	OMIM: 612839; MGI: 2443298; HomoloGene: 49498; GeneCards: TET2; OMA:TET2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	105,279,816 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	133,250,900 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; amniotic fluid; ; epithelium of nasopharynx; ; germinal epithelium; ; bone marrow cells; ; gingival epithelium; ; mucosa of ileum; ; nasal epithelium; ; monocyte; ; visceral pleura;
	Top expressed in
	urethra; ; Rostral migratory stream; ; trophoblast giant cell; ; pineal gland; ; hand; ; vas deferens; ; neural layer of retina; ; otolith organ; ; utricle; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; oxidoreductase activity; dioxygenase activity; zinc ion binding; DNA binding; ferrous iron binding; methylcytosine dioxygenase activity; iron ion binding;
Cellular component	nucleus;
Biological process	5-methylcytosine catabolic process; cell cycle; response to organic cyclic compound; protein O-linked glycosylation; myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; DNA demethylation; histone H3-K4 trimethylation; chromatin organization; oxidative demethylation;
	Sources:Amigo / QuickGO
Orthologs
	54790
	214133
	ENSG00000168769
	ENSMUSG00000040943
	Q6N021
	Q4JK59
	NM_001127208; NM_017628
	NM_001040400; NM_145989; NM_001346736
	NP_001120680; NP_060098
	NP_001035490; NP_001333665
	Wikidata
View/Edit Human	View/Edit Mouse

Tet methylcytosine dioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies.