TFAP4

TFAP4
Identifiers
Aliases	TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4), transcription factor AP-4
External IDs	OMIM: 600743; MGI: 103239; HomoloGene: 2424; GeneCards: TFAP4; OMA:TFAP4 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	4,273,075 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	4,377,718 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; beta cell; ; vena cava; ; sural nerve; ; ganglionic eminence; ; cerebellar hemisphere; ; lateral nuclear group of thalamus; ; subthalamic nucleus; ; nasal epithelium; ; right hemisphere of cerebellum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; yolk sac; ; epiblast; ; female urethra; ; muscle of thigh; ; lip; ; zygote; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein homodimerization activity; protein dimerization activity; transcription coactivator activity; histone deacetylase binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA binding; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	transcription repressor complex; nucleus; mitochondrion;
Biological process	negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; transcription, DNA-templated; negative regulation of gene expression; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; cellular response to dexamethasone stimulus; negative regulation of DNA binding; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; positive regulation of apoptotic process; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of mitotic cell cycle phase transition; protein-containing complex assembly; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7023
	83383
	ENSG00000090447
	ENSMUSG00000005718
	Q01664
	Q9JIZ5
	NM_003223
	NM_031182
	NP_003214
	NP_112459
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.