Trefoil factor 2

TFF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DYZ, 2DZ0, 2DZ1
Identifiers
Aliases	TFF2, SML1, SP, trefoil factor 2
External IDs	OMIM: 182590; MGI: 1306805; HomoloGene: 3956; GeneCards: TFF2; OMA:TFF2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,350,997 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,363,256 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gastric mucosa; ; pylorus; ; gallbladder; ; body of stomach; ; gonad; ; duodenum; ; fundus; ; islet of Langerhans; ; cardia;
	Top expressed in
	mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; duodenum; ; islet of Langerhans; ; trachea; ; gallbladder; ; respiratory epithelium; ; olfactory epithelium; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; CXCR4 chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	wound healing; maintenance of gastrointestinal epithelium; negative regulation of gastric acid secretion; chemokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7032
	21785
	ENSG00000160181
	ENSMUSG00000024028
	Q03403
	Q03404; Q9QX97
	NM_005423
	NM_009363
	NP_005414
	NP_033389
	Wikidata
View/Edit Human	View/Edit Mouse

Trefoil factor 2 is a protein that in humans is encoded by the TFF2 gene.

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.