TGFB1I1

TGFB1I1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Identifiers
Aliases	TGFB1I1, ARA55, HIC-5, HIC5, TSC-5, transforming growth factor beta 1 induced transcript 1
External IDs	OMIM: 602353; MGI: 102784; HomoloGene: 7572; GeneCards: TGFB1I1; OMA:TGFB1I1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,477,960 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,854,871 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; body of uterus; ; myometrium; ; popliteal artery; ; tibial arteries; ; left uterine tube; ; thoracic aorta; ; right coronary artery; ; ascending aorta; ; tail of epididymis;
	Top expressed in
	ascending aorta; ; tunica media of zone of aorta; ; atrium; ; external carotid artery; ; internal carotid artery; ; calvaria; ; aortic valve; ; lumbar spinal ganglion; ; umbilical cord; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	I-SMAD binding; transcription coactivator activity; metal ion binding; protein binding; androgen receptor binding; Roundabout binding; transcription coregulator activity;
Cellular component	cytoplasm; focal adhesion; nuclear matrix; extracellular matrix; intracellular anatomical structure; cell junction; cytoskeleton; nucleus; collagen-containing extracellular matrix; cytosol; plasma membrane;
Biological process	androgen receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; response to heat; negative regulation of transforming growth factor beta receptor signaling pathway; Wnt signaling pathway; transcription by RNA polymerase II; positive regulation of epithelial to mesenchymal transition; ubiquitin-dependent SMAD protein catabolic process; positive regulation of transcription, DNA-templated; cell adhesion; negative regulation of cell population proliferation; morphogenesis of embryonic epithelium; epithelial cell differentiation; cell fate commitment; negative regulation of fat cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7041
	21804
	ENSG00000140682
	ENSMUSG00000030782
	O43294
	Q62219
	NM_015927; NM_001042454; NM_001164719
	NM_001289550; NM_001289551; NM_001289552; NM_001289553; NM_009365
	NP_001035919; NP_001158191; NP_057011; NP_001158191.1; NP_057011.2
	NP_001276479; NP_001276480; NP_001276481; NP_001276482
	Wikidata
View/Edit Human	View/Edit Mouse

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene. Often put together with and studied alongside TGFB1I1 is the mouse homologue HIC-5 ( Hydrogen Peroxide-Inducible Clone-5). As the name suggests, TGFB1I1 is an induced form of the larger family of TGFB1. Studies suggest TGFB1I1 plays a role in processes of cell growth, proliferation, migration, differentiation and senescence. TGFB1I1 is most localized at focal adhesion complexes of cells, although it may be found active in the cytosol, nucleus and cell membrane as well.