Homeobox protein TGIF1

TGIF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LK2
Identifiers
Aliases	TGIF1, HPE4, TGIF, TGFB induced factor homeobox 1
External IDs	OMIM: 602630; MGI: 1194497; HomoloGene: 7574; GeneCards: TGIF1; OMA:TGIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	3,459,978 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	71,160,541 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gallbladder; ; ventricular zone; ; corpus epididymis; ; rectum; ; gastric mucosa; ; right uterine tube; ; left uterine tube; ; cartilage tissue; ; skin of abdomen;
	Top expressed in
	tail of embryo; ; genital tubercle; ; saccule; ; embryo; ; ectoderm; ; otic vesicle; ; otic placode; ; epiblast; ; lip; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; co-SMAD binding;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of gene expression; multicellular organism development; cellular response to growth factor stimulus; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	7050
	21815
	ENSG00000177426
	ENSMUSG00000047407
	Q15583
	P70284
NM_001278682; NM_001278684; NM_001278686; NM_003244; NM_170695;
	NM_173207; NM_173208; NM_173209; NM_173210; NM_173211; NM_174886; NM_001374396; NM_001374397
	NM_001164074; NM_001164075; NM_001164076; NM_001164077; NM_009372
NP_001265611; NP_001265613; NP_001265615; NP_003235; NP_733796;
	NP_775299; NP_775300; NP_775301; NP_775302; NP_775303; NP_777480; NP_001361325; NP_001361326
	NP_001157546; NP_001157547; NP_001157548; NP_001157549; NP_033398
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein TGIF1 is a protein that, in humans, is encoded by the TGIF1 gene. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.