TGIF2

TGIF2
Identifiers
Aliases	TGIF2, TGFB induced factor homeobox 2
External IDs	OMIM: 607294; MGI: 1915299; HomoloGene: 32514; GeneCards: TGIF2; OMA:TGIF2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	36,593,950 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,697,490 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; sural nerve; ; gonad; ; buccal mucosa cell; ; granulocyte; ; right uterine tube; ; testicle; ; monocyte;
	Top expressed in
	ventricular zone; ; zygote; ; phalanx of finger; ; epiblast; ; tail of embryo; ; genital tubercle; ; embryo; ; thumb; ; mandibular prominence; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; retina development in camera-type eye; regulation of gastrulation; positive regulation of neuron differentiation; nodal signaling pathway; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	60436
	228839
	ENSG00000118707
	ENSMUSG00000062175
	Q9GZN2
	Q8C0Y1
	NM_021809; NM_001199513; NM_001199514; NM_001199515
	NM_001291124; NM_173396
	NP_001186442; NP_001186443; NP_001186444; NP_068581
	NP_001278053; NP_775572
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.