Thyroid hormone receptor beta

THRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC, 4ZO1
Identifiers
Aliases	THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta
External IDs	OMIM: 190160; MGI: 98743; HomoloGene: 36025; GeneCards: THRB; OMA:THRB - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	24,495,756 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	4,809,435 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; tibia; ; postcentral gyrus; ; endothelial cell; ; superior frontal gyrus; ; entorhinal cortex; ; Achilles tendon; ; lactiferous duct; ; parotid gland;
	Top expressed in
	auditory system; ; spiral ganglion; ; neural layer of retina; ; organ of Corti; ; right kidney; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; muscle of thigh; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; transcription corepressor activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; protein binding; enzyme binding; chromatin DNA binding; thyroid hormone binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity; nuclear receptor activity;
Cellular component	nucleoplasm; nucleus; nuclear body; RNA polymerase II transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; regulation of heart contraction; female courtship behavior; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; hearing; type I pneumocyte differentiation; negative regulation of female receptivity; animal organ morphogenesis; transcription initiation from RNA polymerase II promoter; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; transcription, DNA-templated; negative regulation of eye photoreceptor cell development; retinal cone cell development; retinal cone cell apoptotic process; multicellular organism development; hormone-mediated signaling pathway; cell differentiation; thyroid gland development; response to lipid; thyroid hormone mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7068
	21834
	ENSG00000151090
	ENSMUSG00000021779
	P10828
	P37242
NM_000461; NM_001128176; NM_001128177; NM_001252634; NM_001354708;
	NM_001354709; NM_001354710; NM_001354711; NM_001354712; NM_001354713; NM_001354714; NM_001354715; NM_001374822; NM_001374823; NM_001374824; NM_001374825; NM_001374826; NM_001374827
	NM_001113417; NM_009380
NP_000452; NP_001121648; NP_001121649; NP_001239563; NP_001341637;
	NP_001341638; NP_001341639; NP_001341640; NP_001341641; NP_001341642; NP_001341643; NP_001341644; NP_001361751; NP_001361752; NP_001361753; NP_001361754; NP_001361755; NP_001361756
	NP_001106888; NP_033406
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.