THRSP

THRSP
Identifiers
Aliases	THRSP, LPGP1, Lpgp, S14, SPOT14, THRP, thyroid hormone responsive
External IDs	OMIM: 601926; MGI: 109126; HomoloGene: 2441; GeneCards: THRSP; OMA:THRSP - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	78,068,351 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,066,937 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vena cava; ; vulva; ; right lobe of liver; ; subcutaneous adipose tissue; ; skin of hip; ; lactiferous gland; ; parotid gland; ; synovial joint;
	Top expressed in
	tunica adventitia of aorta; ; brown adipose tissue; ; white adipose tissue; ; lactiferous gland; ; subcutaneous adipose tissue; ; intercostal muscle; ; tunica media of zone of aorta; ; left lobe of liver; ; parotid gland; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; identical protein binding; protein binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	regulation of lipid biosynthetic process; regulation of transcription, DNA-templated; transcription, DNA-templated; lipid metabolism; regulation of triglyceride biosynthetic process; carnitine shuttle; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	7069
	21835
	ENSG00000151365
	ENSMUSG00000035686
	Q92748
	Q62264
	NM_003251
	NM_009381
	NP_003242
	NP_033407
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior. Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.