TIA1

TIA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MJN, 3BS9
Identifiers
Aliases	TIA1, TIA-1, WDM, TIA1 cytotoxic granule-associated RNA binding protein, TIA1 cytotoxic granule associated RNA binding protein
External IDs	OMIM: 603518; MGI: 107914; HomoloGene: 20692; GeneCards: TIA1; OMA:TIA1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,410,387 bp
Gene ontology
Molecular function	nucleic acid binding; protein binding; poly(A) binding; RNA binding; mRNA 3'-UTR AU-rich region binding;
Cellular component	cytoplasm; cytoplasmic stress granule; nuclear stress granule; nucleus; nucleoplasm; cytosol; ribonucleoprotein complex;
Biological process	negative regulation of translation; positive regulation of epithelial cell apoptotic process; regulation of mRNA splicing, via spliceosome; protein localization to cytoplasmic stress granule; apoptotic process; fibroblast growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7072
	21841
	ENSG00000116001
	ENSMUSG00000071337
	P31483
	P52912
	NM_022037; NM_022173
	NM_001164078; NM_001164079; NM_011585
NP_071320; NP_071505; NP_001338437; NP_001338438; NP_001338439;
	NP_001338440; NP_001338441; NP_001338443; NP_001338444; NP_001338445; NP_001338446; NP_001338447; NP_001338448; NP_001338449; NP_001338450; NP_001338451; NP_001338452; NP_001338453; NP_001338454; NP_001338442
	NP_001157550; NP_001157551; NP_035715
	Wikidata
View/Edit Human	View/Edit Mouse

TIA1 or Tia1 cytotoxic granule-associated rna binding protein is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein. Under stress conditions, TIA1 localizes to cellular RNA-protein conglomerations called stress granules. It is encoded by the TIA1 gene.

Mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, and Welander distal myopathy. It also plays a crucial role in the development of toxic oligomeric tau in Alzheimer's disease.