T-cell lymphoma invasion and metastasis-inducing protein 1

TIAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR
Identifiers
Aliases	TIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1, T-cell lymphoma invasion and metastasis 1
External IDs	OMIM: 600687; MGI: 103306; HomoloGene: 2443; GeneCards: TIAM1; OMA:TIAM1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	89,940,657 bp
RNA expression pattern
	n/a
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; olfactory tubercle; ; lobe of cerebellum; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; cerebellar vermis; ; medial dorsal nucleus; ; piriform cortex;
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule binding; kinase binding; protein binding; lipid binding; guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; cell-cell contact zone; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; dendritic spine; axonal growth cone; synapse; main axon; ruffle membrane; cell junction; soma; somatodendritic compartment; microtubule; nucleus; postsynaptic density; glutamatergic synapse; extrinsic component of postsynaptic density membrane;
Biological process	protein localization to membrane; apoptotic process; regulation of insulin secretion involved in cellular response to glucose stimulus; intracellular signal transduction; activation of GTPase activity; positive regulation of JUN kinase activity; ephrin receptor signaling pathway; cardiac muscle hypertrophy; regulation of non-canonical Wnt signaling pathway; positive regulation of axonogenesis; neuron projection extension; Wnt signaling pathway, planar cell polarity pathway; regulation of dopaminergic neuron differentiation; regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; positive regulation of apoptotic process; positive regulation of Schwann cell chemotaxis; positive regulation of protein binding; cell-matrix adhesion; Rac protein signal transduction; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; cell migration; positive regulation of dendritic spine morphogenesis; signal transduction; response to cocaine; positive regulation of cell population proliferation; positive regulation of cell migration; NMDA selective glutamate receptor signaling pathway; regulation of modification of postsynaptic actin cytoskeleton; regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7074
	21844
	ENSG00000156299
	ENSMUSG00000002489
	Q13009
	Q60610
	NM_003253
	NM_001145886; NM_001145887; NM_009384
NP_003244; NP_001340613; NP_001340614; NP_001340615; NP_001340616;
	NP_001340617; NP_001340618; NP_001340619; NP_001340620; NP_001340621; NP_001340622; NP_001340623
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.