TIMP1

TIMP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96
Identifiers
Aliases	TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
External IDs	OMIM: 305370; MGI: 98752; HomoloGene: 36321; GeneCards: TIMP1; OMA:TIMP1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	47,586,789 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	20,740,974 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; gallbladder; ; left coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; stromal cell of endometrium; ; islet of Langerhans; ; pericardium; ; beta cell; ; right adrenal gland;
	Top expressed in
	calvaria; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; body of femur; ; ankle joint; ; ankle; ; gastrula; ; lactiferous gland; ; fossa; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; cytokine activity; metal ion binding; protease binding; protein binding; metalloendopeptidase inhibitor activity; growth factor activity; zinc ion binding;
Cellular component	extracellular matrix; extracellular region; basement membrane; extracellular exosome; platelet alpha granule lumen; extracellular space; endoplasmic reticulum lumen; collagen;
Biological process	response to cytokine; negative regulation of peptidase activity; ageing; response to peptide hormone; platelet degranulation; wound healing; negative regulation of apoptotic process; extracellular matrix disassembly; negative regulation of trophoblast cell migration; response to organic substance; cell activation; cartilage development; regulation of integrin-mediated signaling pathway; positive regulation of cell population proliferation; response to hormone; negative regulation of membrane protein ectodomain proteolysis; negative regulation of endopeptidase activity; negative regulation of catalytic activity; negative regulation of metallopeptidase activity; post-translational protein modification; regulation of signaling receptor activity; connective tissue replacement involved in inflammatory response wound healing; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7076
	21857
	ENSG00000102265
	ENSMUSG00000001131
	P01033; Q6FGX5
	P12032
	NM_003254
	NM_001044384; NM_001294280; NM_011593
	NP_003245; NP_003245.1
	NP_001037849; NP_001281209; NP_035723
	Wikidata
View/Edit Human	View/Edit Mouse

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a two-domain glycoprotein with a molecular weight of 28 kDa. TIMP1 is expressed in several tissues of organisms.

This protein is a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.