TIMP2

TIMP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BR9, 1GXD, 2TMP, 4ILW
Identifiers
Aliases	TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2
External IDs	OMIM: 188825; MGI: 98753; HomoloGene: 2444; GeneCards: TIMP2; OMA:TIMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,925,387 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,246,566 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; synovial joint; ; stromal cell of endometrium; ; tibia; ; urethra; ; Descending thoracic aorta; ; trigeminal ganglion; ; ascending aorta; ; right coronary artery; ; visceral pleura;
	Top expressed in
	calvaria; ; stroma of bone marrow; ; ankle; ; skin of external ear; ; body of femur; ; ventromedial nucleus; ; subiculum; ; anterior amygdaloid area; ; endothelial cell of lymphatic vessel; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metal ion binding; integrin binding; protein binding; protease binding; metalloendopeptidase inhibitor activity; zinc ion binding;
Cellular component	growth cone; extracellular region; cell surface; soma; neuron projection; extracellular exosome; extracellular matrix; extracellular space; specific granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen; collagen-containing extracellular matrix;
Biological process	negative regulation of proteolysis; response to cytokine; negative regulation of peptidase activity; positive regulation of adenylate cyclase activity; ageing; extracellular matrix disassembly; negative regulation of Ras protein signal transduction; central nervous system development; positive regulation of neuron differentiation; response to hormone; negative regulation of membrane protein ectodomain proteolysis; positive regulation of MAPK cascade; negative regulation of cell population proliferation; negative regulation of mitotic cell cycle; regulation of Rap protein signal transduction; negative regulation of endopeptidase activity; neutrophil degranulation; negative regulation of metallopeptidase activity; response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	7077
	21858
	ENSG00000035862
	ENSMUSG00000017466
	P16035
	P25785
	NM_003255
	NM_011594
	NP_003246
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.