TIMP3

TIMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CKI
Identifiers
Aliases	TIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDs	OMIM: 188826; MGI: 98754; HomoloGene: 36322; GeneCards: TIMP3; OMA:TIMP3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,863,041 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	86,185,370 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; decidua; ; retinal pigment epithelium; ; urethra; ; right lung; ; lower lobe of lung; ; vena cava; ; saphenous vein; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	retinal pigment epithelium; ; right kidney; ; ciliary body; ; right lung; ; human kidney; ; right lung lobe; ; carotid body; ; aortic valve; ; skin of external ear; ; iris;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metal ion binding; protease binding; protein binding; metalloendopeptidase inhibitor activity;
Cellular component	extracellular matrix; basement membrane; extracellular exosome; nucleus; extracellular region; platelet dense granule lumen; extracellular space; collagen-containing extracellular matrix;
Biological process	cellular response to organic substance; negative regulation of peptidase activity; response to stimulus; positive regulation of TRAIL-activated apoptotic signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; visual perception; platelet degranulation; response to organic substance; negative regulation of metalloendopeptidase activity; response to hormone; negative regulation of endopeptidase activity; response to cytokine;
	Sources:Amigo / QuickGO
Orthologs
	7078
	21859
	ENSG00000100234
	ENSMUSG00000020044
	P35625
	P39876
	NM_000362
	NM_011595
	NP_000353
	NP_035725
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.