TIMP4

TIMP4
Identifiers
Aliases	TIMP4, TIMP metallopeptidase inhibitor 4, TIMP-4
External IDs	OMIM: 601915; MGI: 109125; HomoloGene: 37748; GeneCards: TIMP4; OMA:TIMP4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	12,158,912 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,229,166 bp
RNA expression pattern
	Top expressed in
	abdominal fat; ; subcutaneous adipose tissue; ; thoracic aorta; ; left coronary artery; ; ascending aorta; ; apex of heart; ; synovial joint; ; right hemisphere of cerebellum; ; Descending thoracic aorta; ; popliteal artery;
	Top expressed in
	interventricular septum; ; white adipose tissue; ; lobe of cerebellum; ; cerebellar vermis; ; lumbar subsegment of spinal cord; ; motor neuron; ; deep cerebellar nuclei; ; tunica media of zone of aorta; ; substantia nigra; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; metal ion binding; protease binding; metalloendopeptidase inhibitor activity;
Cellular component	sarcomere; extracellular region; extracellular space; extracellular matrix;
Biological process	Notch signaling pathway; negative regulation of peptidase activity; response to peptide hormone; central nervous system development; response to lipopolysaccharide; ovulation cycle; negative regulation of membrane protein ectodomain proteolysis; negative regulation of catalytic activity; negative regulation of endopeptidase activity; response to hormone; response to cytokine; biological process; response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	7079
	110595
	ENSG00000157150
	ENSMUSG00000030317
	Q99727
	Q9JHB3
	NM_003256
	NM_080639; NM_001356406
	NP_003247
	NP_542370; NP_001343335
	Wikidata
View/Edit Human	View/Edit Mouse

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.