Tight junction protein ZO-2

TJP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OSG, 3E17
Identifiers
Aliases	TJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2, FHCA1
External IDs	OMIM: 607709; MGI: 1341872; HomoloGene: 3541; GeneCards: TJP2; OMA:TJP2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	69,274,615 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	24,202,394 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; C1 segment; ; right lung; ; subcutaneous adipose tissue; ; duodenum; ; right lobe of liver; ; right lobe of thyroid gland;
	Top expressed in
	otic vesicle; ; saccule; ; otic placode; ; vestibular membrane of cochlear duct; ; Paneth cell; ; sciatic nerve; ; conjunctival fornix; ; left lung lobe; ; epithelium of stomach; ; cornea;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein domain specific binding; guanylate kinase activity; protein binding; cadherin binding;
Cellular component	membrane; bicellular tight junction; adherens junction; plasma membrane; cell junction; nucleus; cytosol; nucleoplasm;
Biological process	establishment of endothelial intestinal barrier; hippo signaling; regulation of membrane permeability; intestinal absorption; GMP metabolic process; GDP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9414
	21873
	ENSG00000119139
	ENSMUSG00000024812
	Q9UDY2
	Q9Z0U1
NM_001170414; NM_001170415; NM_001170416; NM_001170630; NM_004817;
	NM_201629; NM_001369870; NM_001369871; NM_001369872; NM_001369873; NM_001369874; NM_001369875
	NM_001198985; NM_011597; NM_001360391; NM_001360392; NM_001376368
	NP_001163885; NP_001163886; NP_001163887; NP_004808; NP_963923
	NP_001185914; NP_035727; NP_001347320; NP_001347321
	Wikidata
View/Edit Human	View/Edit Mouse

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].