TLE3

TLE3
Identifiers
Aliases	TLE3, ESG, ESG3, GRG3, HsT18976, transducin like enhancer of split 3, TLE family member 3, transcriptional corepressor
External IDs	OMIM: 600190; MGI: 104634; HomoloGene: 21059; GeneCards: TLE3; OMA:TLE3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,098,176 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	61,325,779 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; sural nerve; ; ventricular zone; ; skin of leg; ; buccal mucosa cell; ; right testis; ; monocyte; ; left testis; ; skin of abdomen;
	Top expressed in
	genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; granulocyte; ; decidua; ; ventricular zone; ; hair follicle; ; lacrimal gland; ; intestinal villus; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription corepressor activity;
Cellular component	nucleus; nucleoplasm; beta-catenin-TCF complex; transcription regulator complex;
Biological process	animal organ morphogenesis; regulation of transcription, DNA-templated; Wnt signaling pathway; transcription, DNA-templated; signal transduction; beta-catenin-TCF complex assembly; negative regulation of canonical Wnt signaling pathway; negative regulation of cold-induced thermogenesis; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	7090
	21887
	ENSG00000140332
	ENSMUSG00000032280
	Q04726; Q6PRX3
	Q08122
NM_001105192; NM_001282979; NM_001282980; NM_001282981; NM_001282982;
	NM_005078; NM_020908
	NM_001083927; NM_001083928; NM_009389
NP_001098662; NP_001269908; NP_001269909; NP_001269910; NP_001269911;
	NP_005069; NP_065959; NP_001269908.1
	NP_001077396; NP_001077397; NP_033415
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 3 is a protein that in humans is encoded by the TLE3 gene.

TLE3 expression has been linked to higher survival rates for lung cancer patients.