TLL2

TLL2
Identifiers
Aliases	TLL2, tolloid like 2
External IDs	OMIM: 606743; MGI: 1346044; HomoloGene: 56545; GeneCards: TLL2; OMA:TLL2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,513,926 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,195,274 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; apex of heart; ; testicle; ; left ventricle; ; Brodmann area 23; ; right ventricle; ; C1 segment; ; middle temporal gyrus; ; muscle of thigh;
	Top expressed in
	embryo; ; tail of embryo; ; esophagus; ; stria vascularis; ; Mesencephalon; ; ovary;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; serine-type endopeptidase activity;
Cellular component	extracellular region;
Biological process	multicellular organism development; cell differentiation; extracellular matrix disassembly; negative regulation of skeletal muscle tissue growth; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	7093
	24087
	ENSG00000095587
	ENSMUSG00000025013
	Q9Y6L7
	Q9WVM6
	NM_012465
	NM_011904
	NP_036597
	NP_036034
	Wikidata
View/Edit Human	View/Edit Mouse

Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene.

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.