TLN1

TLN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SYQ, 2MWN, 4DJ9
Identifiers
Aliases	TLN1, ILWEQ, TLN, talin 1, talin-1
External IDs	OMIM: 186745; MGI: 1099832; HomoloGene: 21267; GeneCards: TLN1; OMA:TLN1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,732,195 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,562,691 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; ascending aorta; ; right coronary artery; ; Descending thoracic aorta; ; left coronary artery; ; muscle layer of sigmoid colon; ; gastric mucosa; ; body of uterus; ; stromal cell of endometrium;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; ascending aorta; ; superior surface of tongue; ; gallbladder; ; left lung; ; external carotid artery; ; aortic valve; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of cytoskeleton; actin filament binding; LIM domain binding; integrin binding; protein binding; vinculin binding; protein-containing complex binding; actin binding; cadherin binding; phosphatidylserine binding; phosphatidylinositol binding;
Cellular component	cytoskeleton; cell projection; ruffle membrane; ruffle; cytosol; extracellular exosome; membrane; cell surface; cell-cell junction; cell junction; focal adhesion; extracellular region; cytoplasm; plasma membrane;
Biological process	cell-substrate junction assembly; IRE1-mediated unfolded protein response; muscle contraction; platelet degranulation; platelet aggregation; cell-cell junction assembly; cortical actin cytoskeleton organization; cell adhesion; viral process; integrin-mediated signaling pathway; integrin activation;
	Sources:Amigo / QuickGO
Orthologs
	7094
	21894
	ENSG00000137076
	ENSMUSG00000028465
	Q9Y490
	P26039
	NM_006289
	NM_011602
	NP_006280
	NP_035732
	Wikidata
View/Edit Human	View/Edit Mouse

Talin-1 is a protein that in humans is encoded by the TLN1 gene. Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been observed in patients with heart failure, however no mutations in TLN1 have been linked with specific diseases.