Toll-like receptor 1

TLR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z7X, 1FYV
Identifiers
Aliases	TLR1, CD281, TIL, TIL. LPRS5, rsc786, toll like receptor 1
External IDs	OMIM: 601194; MGI: 1341295; HomoloGene: 20694; GeneCards: TLR1; OMA:TLR1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	38,856,817 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,090,906 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow cells; ; Achilles tendon; ; granulocyte; ; appendix; ; gallbladder; ; spleen; ; lymph node; ; periodontal fiber;
	Top expressed in
	mesenteric lymph nodes; ; left colon; ; spleen; ; blood; ; submandibular gland; ; external carotid artery; ; internal carotid artery; ; subcutaneous adipose tissue; ; stroma of bone marrow; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Toll-like receptor 2 binding; protein binding; protein heterodimerization activity; lipopeptide binding; transmembrane signaling receptor activity; signaling receptor activity; identical protein binding;
Cellular component	integral component of membrane; phagocytic vesicle membrane; Golgi apparatus; membrane; plasma membrane; Toll-like receptor 1-Toll-like receptor 2 protein complex; integral component of plasma membrane; membrane raft; cytoplasmic vesicle;
Biological process	defense response; toll-like receptor TLR1:TLR2 signaling pathway; immune system process; MyD88-dependent toll-like receptor signaling pathway; cellular response to triacyl bacterial lipopeptide; detection of triacyl bacterial lipopeptide; toll-like receptor 1 signaling pathway; macrophage activation; inflammatory response; signal transduction; innate immune response; defense response to bacterium; cell activation; toll-like receptor signaling pathway; immune response; positive regulation of toll-like receptor 2 signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7096
	21897
	ENSG00000174125
	ENSMUSG00000044827
	Q15399
	Q9EPQ1
	NM_003263
	NM_001276445; NM_030682
	NP_003254
	NP_001263374; NP_109607
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 1 (TLR1) is a member of the toll-like receptor (TLR) family of pattern recognition receptors (PRRs) that form the cornerstone of the innate immune system. TLR1 recognizes bacterial lipoproteins and glycolipids in complex with TLR2. TLR1 is a cell surface receptor. In humans, TLR1 is encoded by the TLR1 gene, which is located on chromosome 4.