Toll-like receptor 8

TLR8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA
Identifiers
Aliases	TLR8, CD288, toll like receptor 8, hIMD98
External IDs	OMIM: 300366; MGI: 2176887; HomoloGene: 44054; GeneCards: TLR8; OMA:TLR8 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	12,923,169 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	166,047,325 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; visceral pleura; ; trabecular bone; ; bone marrow; ; spleen; ; appendix; ; parietal pleura; ; lower lobe of lung;
	Top expressed in
	granulocyte; ; zygote; ; embryo; ; stroma of bone marrow; ; secondary oocyte; ; calvaria; ; esophagus; ; muscle of thigh; ; spleen; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; identical protein binding; RNA binding; double-stranded RNA binding; single-stranded RNA binding; transmembrane signaling receptor activity; signaling receptor activity; pattern recognition receptor activity;
Cellular component	endoplasmic reticulum membrane; membrane; Golgi membrane; endolysosome membrane; endosome membrane; integral component of plasma membrane; external side of plasma membrane; integral component of membrane; plasma membrane;
Biological process	regulation of protein phosphorylation; immune system process; response to virus; MyD88-dependent toll-like receptor signaling pathway; microglial cell activation; cellular response to mechanical stimulus; defense response to virus; immunoglobulin mediated immune response; positive regulation of innate immune response; toll-like receptor 9 signaling pathway; I-kappaB kinase/NF-kappaB signaling; signal transduction; innate immune response; inflammatory response; toll-like receptor signaling pathway; toll-like receptor 8 signaling pathway; immune response; positive regulation of interleukin-6 production;
	Sources:Amigo / QuickGO
Orthologs
	51311
	170744
	ENSG00000101916
	ENSMUSG00000040522
	Q9NR97
	P58682
	NM_016610; NM_138636
	NM_133212; NM_001313760; NM_001313761
	NP_057694; NP_619542
	NP_001300689; NP_001300690; NP_573475
	Wikidata
View/Edit Human	View/Edit Mouse

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.