| TSPAN7 |
|---|
|
| Identifiers |
|---|
| Aliases | TSPAN7, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b, tetraspanin 7, XLID58 |
|---|
| External IDs | OMIM: 300096; MGI: 1298407; HomoloGene: 20967; GeneCards: TSPAN7; OMA:TSPAN7 - orthologs |
|---|
|
| Gene location (Mouse) |
|---|
| | Chr. | X chromosome (mouse) |
|---|
| | Band | X|X A1.1 | Start | 10,351,397 bp |
|---|
| End | 10,462,844 bp |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - caudate nucleus
- nucleus accumbens
- dorsolateral prefrontal cortex
- prefrontal cortex
- putamen
- right frontal lobe
- Brodmann area 9
- cerebellar cortex
- frontal pole
- cerebellar hemisphere
|
| | Top expressed in | - dentate gyrus of hippocampal formation granule cell
- perirhinal cortex
- entorhinal cortex
- CA3 field
- superior frontal gyrus
- primary visual cortex
- nucleus of stria terminalis
- primary motor cortex
- dorsal striatum
- prefrontal cortex
|
| | More reference expression data |
|
|---|
| BioGPS | |
|---|
|
|
| Wikidata |
|
Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. More recently, it has been identified as a key immune system target in type 1 diabetes.
