TMED10

TMED10
Identifiers
Aliases	TMED10, P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1, transmembrane p24 trafficking protein 10
External IDs	OMIM: 605406; MGI: 3782198; HomoloGene: 4972; GeneCards: TMED10; OMA:TMED10 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,176,612 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; islet of Langerhans; ; stromal cell of endometrium; ; germinal epithelium; ; beta cell; ; corpus epididymis; ; caput epididymis; ; olfactory zone of nasal mucosa; ; mucosa of sigmoid colon; ; skin of thigh;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; syntaxin binding; protein-containing complex binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; secretory granule membrane; membrane; intracellular membrane-bounded organelle; melanosome; Golgi membrane; cis-Golgi network; plasma membrane; transport vesicle membrane; transport vesicle; zymogen granule membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; trans-Golgi network transport vesicle; endoplasmic reticulum-Golgi intermediate compartment membrane; gamma-secretase complex; cytoplasmic vesicle; COPI-coated vesicle; endoplasmic reticulum-Golgi intermediate compartment; COPII-coated ER to Golgi transport vesicle;
Biological process	regulation of amyloid-beta formation; Golgi organization; kidney development; COPI coating of Golgi vesicle; vesicle targeting, to, from or within Golgi; COPI-coated vesicle budding; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; response to alkaloid; protein complex oligomerization; vesicle cargo loading; protein transport; regulated exocytosis; intracellular protein transport; vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
	10972
	100042773
	ENSG00000170348
	ENSMUSG00000114251
	P49755
	n/a
	NM_006827
	XM_036158265
	NP_006818
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane emp24 domain-containing protein 10 is a protein that in humans is encoded by the TMED10 gene.

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.