TMEM127

TMEM127
Identifiers
Aliases	TMEM127, transmembrane protein 127
External IDs	OMIM: 613403; MGI: 1916720; HomoloGene: 9877; GeneCards: TMEM127; OMA:TMEM127 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,265,997 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,103,027 bp
RNA expression pattern
	Top expressed in
	white blood cell; ; monocyte; ; blood; ; left ventricle; ; stromal cell of endometrium; ; buccal mucosa cell; ; apex of heart; ; endothelial cell; ; granulocyte; ; gallbladder;
	Top expressed in
	otolith organ; ; utricle; ; ascending aorta; ; aortic valve; ; supraoptic nucleus; ; conjunctival fornix; ; granulocyte; ; facial motor nucleus; ; stroma of bone marrow; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; early endosome; membrane;
Biological process	regulation of TOR signaling; endosome organization; negative regulation of cell population proliferation; negative regulation of TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	55654
	69470
	ENSG00000135956
	ENSMUSG00000034850
	O75204
	Q8BGP5
	NM_032218; NM_001193304; NM_017849
	NM_175145; NM_001362704
	NP_001180233; NP_060319
	NP_780354; NP_001349633
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 127 (TMEM127) is a transmembrane protein which is encoded by the TMEM127 gene. It has been demonstrated to be a negative regulator MTOR signalling. TMEM127 is a tumor suppressor gene, inactivating germline mutations in which causes hereditary pheochromocytoma and paraganglioma.