TMEM158

TMEM158
Identifiers
Aliases	TMEM158, BBP, RIS1, p40BBP, transmembrane protein 158 (gene/pseudogene), transmembrane protein 158
External IDs	MGI: 1919559; HomoloGene: 9141; GeneCards: TMEM158; OMA:TMEM158 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,226,287 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,089,829 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; ganglionic eminence; ; myometrium; ; periodontal fiber; ; tail of epididymis; ; entorhinal cortex; ; body of uterus;
	Top expressed in
	dorsal striatum; ; olfactory tubercle; ; lateral septal nucleus; ; nucleus accumbens; ; ventromedial nucleus; ; anterior amygdaloid area; ; barrel cortex; ; globus pallidus; ; supraoptic nucleus; ; gastrula;
	More reference expression data
	n/a
Orthologs
	25907
	72309
	ENSG00000249992
	ENSMUSG00000054871
	Q8WZ71
	Q6F5E0
	NM_015444
	NM_001002267
	NP_056259
	NP_001002267
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 158 is a protein that in humans is encoded by the TMEM158 gene.

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence.

The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway