TMEM59

TMEM59
Identifiers
Aliases	TMEM59, C1orf8, HSPC001, DCF1, PRO195, UNQ169, transmembrane protein 59
External IDs	OMIM: 617084; MGI: 1929278; HomoloGene: 3583; GeneCards: TMEM59; OMA:TMEM59 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,053,504 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,058,193 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; parotid gland; ; bronchial epithelial cell; ; right uterine tube; ; C1 segment; ; rectum; ; corpus epididymis; ; stromal cell of endometrium; ; gallbladder; ; mucosa of sigmoid colon;
	Top expressed in
	renal cortex; ; right kidney; ; proximal tubule; ; spermatocyte; ; olfactory epithelium; ; cochlea; ; stomach; ; synovial joint; ; lens; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; protein binding;
Cellular component	integral component of membrane; endosome; late endosome; Golgi apparatus; late endosome membrane; Golgi medial cisterna; membrane; Golgi membrane; plasma membrane; Golgi cis cisterna; lysosomal membrane; Golgi trans cisterna; lysosome; extracellular exosome;
Biological process	positive regulation of autophagy; proteolysis; autophagy; negative regulation of protein processing; negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9528
	56374
	ENSG00000116209
	ENSMUSG00000028618
	Q9BXS4
	Q9QY73
NM_001305043; NM_001305049; NM_001305050; NM_001305051; NM_001305052;
	NM_001305066; NM_004872
	NM_029565
NP_001291972; NP_001291978; NP_001291979; NP_001291980; NP_001291981;
	NP_001291995; NP_004863
	NP_083841
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59 gene.

TMEM59 is a membrane bound protein that is localized to the Golgi apparatus. The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease. Moreover, TMEM59 has been shown to potentiate wnt signaling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficacy of wnt signaling.