TMEM63A

TMEM63A
Identifiers
Aliases	TMEM63A, KIAA0792, transmembrane protein 63A, HLD19
External IDs	MGI: 2384789; HomoloGene: 101673; GeneCards: TMEM63A; OMA:TMEM63A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,882,380 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,802,677 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right uterine tube; ; middle frontal gyrus; ; body of pancreas; ; minor salivary glands; ; corpus callosum; ; buccal mucosa cell; ; granulocyte; ; rectum; ; canal of the cervix;
	Top expressed in
	ascending aorta; ; pyloric antrum; ; aortic valve; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; lip; ; granulocyte; ; submandibular gland; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; calcium activated cation channel activity;
Cellular component	integral component of membrane; lysosomal membrane; lysosome; extracellular exosome; membrane; microtubule organizing center; plasma membrane; specific granule membrane; intracellular membrane-bounded organelle; tertiary granule membrane;
Biological process	ion transport; neutrophil degranulation; transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9725
	208795
	ENSG00000196187
	ENSMUSG00000026519
	O94886
	Q91YT8
	NM_014698
	NM_144794
	NP_055513
	NP_659043
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 63A is a protein that in humans is encoded by the TMEM63A gene. The mature human protein is approximately 92.1 kilodaltons (kDa), with a relatively high conservation of mass in orthologs. The protein contains eleven transmembrane domains and is inserted into the membrane of the lysosome. BioGPS analysis for TMEM63A in humans shows that the gene is ubiquitously expressed, with the highest levels of expression found in T-cells and dendritic cells.