Thymopoietin

TMPO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GJJ, 1H9F, 1H9E
Identifiers
Aliases	TMPO, CMD1T, LAP2, LEMD4, PRO0868, TP, thymopoietin
External IDs	OMIM: 188380; MGI: 106920; HomoloGene: 31144; GeneCards: TMPO; OMA:TMPO - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	98,550,351 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	91,017,177 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; monocyte; ; trabecular bone; ; tonsil; ; lymph node; ; rectum; ; epithelium of colon; ; oocyte;
	Top expressed in
	ectoderm; ; otic vesicle; ; otic placode; ; ventricular zone; ; mandibular prominence; ; saccule; ; maxillary prominence; ; dermis; ; thymus; ; atrium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; lamin binding; cadherin binding; protein binding;
Cellular component	chromatin; nuclear envelope; nucleus; chromosome; cytoplasm; integral component of membrane; nuclear inner membrane; nuclear membrane; membrane;
Biological process	regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	7112
	21917
	ENSG00000120802
	ENSMUSG00000019961
	P42166; P42167
	Q61029; Q61033
	NM_001032283; NM_001032284; NM_001307975; NM_003276
NM_001080129; NM_001080130; NM_001080131; NM_001080132; NM_001080134;
	NM_011605; NM_001283048
NP_001027454; NP_001027455; NP_001294904; NP_003267; NP_001027454.1;
	NP_001027455.1; NP_001294904.1; NP_001027454.1
NP_001073598; NP_001073599; NP_001073600; NP_001073601; NP_001269977;
	NP_035735; NP_035735.2
	Wikidata
View/Edit Human	View/Edit Mouse

Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.

Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.