TMTC4

TMTC4
Identifiers
Aliases	TMTC4, transmembrane and tetratricopeptide repeat containing 4, transmembrane O-mannosyltransferase targeting cadherins 4
External IDs	OMIM: 618203; MGI: 1921050; HomoloGene: 32796; GeneCards: TMTC4; OMA:TMTC4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	100,675,093 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	122,984,035 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ventricular zone; ; ganglionic eminence; ; C1 segment; ; pancreatic epithelial cell; ; mucosa of ileum; ; gonad; ; endothelial cell; ; inferior ganglion of vagus nerve; ; Brodmann area 46;
	Top expressed in
	barrel cortex; ; vas deferens; ; medial ganglionic eminence; ; trigeminal ganglion; ; vestibular sensory epithelium; ; superior cervical ganglion; ; olfactory epithelium; ; lacrimal gland; ; condyle; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	mannosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; transferase activity;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum;
Biological process	protein O-linked mannosylation; protein glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	84899
	70551
	ENSG00000125247
	ENSMUSG00000041594
	Q5T4D3
	Q8BG19
NM_001079669; NM_001286453; NM_032813; NM_001350571; NM_001350572;
	NM_001350574; NM_001350576; NM_001350577
	NM_028651; NM_001360598; NM_001360599
NP_001073137; NP_001273382; NP_116202; NP_001337500; NP_001337501;
	NP_001337503; NP_001337505; NP_001337506
	NP_082927; NP_001347527; NP_001347528
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane and Tetratricopeptide repeat containing 4 is a protein that in humans is encoded by the TMTC4 gene. This protein crosses the plasma membrane 10 times, and resides in the ER lumen and cytosol. The predicted structure of the TMTC4 protein is a series of alpha-helices.