TNFAIP8L2

TNFAIP8L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3F4M
Identifiers
Aliases	TNFAIP8L2, TIPE2, TNF alpha induced protein 8 like 2
External IDs	OMIM: 612112; MGI: 1917019; HomoloGene: 56998; GeneCards: TNFAIP8L2; OMA:TNFAIP8L2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,159,749 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,049,671 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; mucosa of ileum; ; spleen; ; appendix; ; lymph node; ; gonad; ; testicle; ; trabecular bone;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; blood; ; stroma of bone marrow; ; blastocyst; ; spleen; ; subcutaneous adipose tissue; ; thymus; ; jejunum; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm;
Biological process	innate immune response; negative regulation of T cell activation; negative regulation of inflammatory response; immune system process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	79626
	69769
	ENSG00000163154
	ENSMUSG00000013707
	Q6P589
	Q9D8Y7
	NM_024575
	NM_027206
	NP_078851
	NP_081482
	Wikidata
View/Edit Human	View/Edit Mouse

TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.