TNFSF18

TNFSF18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q1M, 2R30, 2R32, 3B93, 3B94
Identifiers
Aliases	TNFSF18, AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
External IDs	OMIM: 603898; MGI: 2673064; HomoloGene: 3732; GeneCards: TNFSF18; OMA:TNFSF18 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	173,050,941 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,332,859 bp
RNA expression pattern
	Top expressed in
	testicle; ; gallbladder; ; stromal cell of endometrium; ; cartilage tissue; ; rectum; ; prefrontal cortex; ; islet of Langerhans; ; Brodmann area 9; ; smooth muscle tissue; ; duodenum;
	Top expressed in
	embryo; ; uterus; ; zone of skin; ; lip; ; spermatid; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; signaling receptor binding; protein binding; tumor necrosis factor receptor superfamily binding; identical protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular space; cell surface;
Biological process	adaptive immune response; positive regulation of leukocyte migration; immune system process; cell-cell signaling; negative regulation of apoptotic process; signal transduction; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; T cell proliferation involved in immune response; tumor necrosis factor-mediated signaling pathway; regulation of T cell proliferation; positive regulation of cell adhesion; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	8995
	240873
	ENSG00000120337
	ENSMUSG00000066755
	Q9UNG2
	Q7TS55
	NM_005092
	NM_183391
	NP_005083
	NP_899247
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.