TNFSF9

TNFSF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X29
Identifiers
Aliases	TNFSF9, 4-1BB-L, CD137L, TNLG5A, tumor necrosis factor superfamily member 9, TNF superfamily member 9
External IDs	OMIM: 606182; MGI: 1101058; HomoloGene: 55782; GeneCards: TNFSF9; OMA:TNFSF9 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,535,924 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,414,757 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; testicle; ; internal globus pallidus; ; vagina; ; Brodmann area 9; ; right frontal lobe; ; upper lobe of left lung; ; prefrontal cortex; ; muscle of thigh; ; cerebellar hemisphere;
	Top expressed in
	gastrula; ; decidua; ; blastocyst; ; embryo; ; embryo; ; cumulus cell; ; humerus; ; ventricular zone; ; medial ganglionic eminence; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding; tumor necrosis factor receptor superfamily binding;
Cellular component	integral component of membrane; membrane; extracellular space; plasma membrane;
Biological process	cell-cell signaling; cell population proliferation; immune response; signal transduction; apoptotic process; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; tumor necrosis factor-mediated signaling pathway; regulation of signaling receptor activity; regulation of T cell proliferation; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8744
	21950
	ENSG00000125657
	ENSMUSG00000035678
	P41273
	P41274
	NM_003811
	NM_009404
	NP_003802
	NP_033430
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene.

4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137). The 4-1BB/4-1BBL complex belongs to the TNFR:TNF superfamily, which is expressed on activated T Lymphocytes.