TNIK

TNIK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X7F, 5CWZ, 5AX9
Identifiers
Aliases	TNIK, TRAF2 and NCK interacting kinase, MRT54
External IDs	OMIM: 610005; MGI: 1916264; HomoloGene: 77943; GeneCards: TNIK; OMA:TNIK - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	171,460,408 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	28,730,007 bp
RNA expression pattern
	Top expressed in
	oocyte; ; caudate nucleus; ; jejunal mucosa; ; secondary oocyte; ; nucleus accumbens; ; putamen; ; corpus callosum; ; internal globus pallidus; ; duodenum; ; Brodmann area 46;
	Top expressed in
	superior cervical ganglion; ; lateral septal nucleus; ; trigeminal ganglion; ; ventromedial nucleus; ; temporal lobe; ; mammillary body; ; lateral hypothalamus; ; superior frontal gyrus; ; Amygdala; ; olfactory bulb;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase kinase activity;
Cellular component	cytoplasm; recycling endosome; endosome; nucleoplasm; apical plasma membrane; extracellular exosome; cytoskeleton; nucleus; cytosol; presynapse; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	actin cytoskeleton reorganization; microvillus assembly; positive regulation of protein phosphorylation; intracellular signal transduction; phosphorylation; Wnt signaling pathway; nervous system development; regulation of dendrite morphogenesis; protein phosphorylation; cytoskeleton organization; protein autophosphorylation; protein localization to plasma membrane; regulation of mitotic cell cycle; regulation of apoptotic process; MAPK cascade; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23043
	665113
	ENSG00000154310
	ENSMUSG00000027692
	Q9UKE5
	P83510
NM_001161560; NM_001161561; NM_001161562; NM_001161563; NM_001161564;
	NM_001161565; NM_001161566; NM_015028
	NM_001163007; NM_001163008; NM_001163009; NM_026910
NP_001155032; NP_001155033; NP_001155034; NP_001155035; NP_001155036;
	NP_001155037; NP_001155038; NP_055843
	NP_001156479; NP_001156480; NP_001156481; NP_081186
	Wikidata
View/Edit Human	View/Edit Mouse

TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. TNIK is involved in various cellular processes, including signal transduction, gene transcription, and cytoskeletal organization. As an emerging area of therapeutic research, TNIK inhibitors have shown potential in addressing a range of diseases, including cancer, neurological disorders, and inflammatory conditions.