TNK2

TNK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CF4, 1U46, 1U4D, 1U54, 3EQP, 3EQR, 4EWH, 4HZR, 4HZS, 4ID7
Identifiers
Aliases	TNK2, ACK, ACK-1, ACK1, p21cdc42Hs, tyrosine kinase non receptor 2
External IDs	OMIM: 606994; MGI: 1858308; HomoloGene: 4224; GeneCards: TNK2; OMA:TNK2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	195,911,945 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,502,311 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Amygdala; ; granulocyte; ; nucleus accumbens; ; anterior pituitary; ; Brodmann area 9; ; putamen;
	Top expressed in
	medial vestibular nucleus; ; substantia nigra; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus; ; neural layer of retina; ; deep cerebellar nuclei; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; epidermal growth factor receptor binding; GTPase inhibitor activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; WW domain binding; protein tyrosine kinase activity; ATP binding; ubiquitin protein ligase binding; non-membrane spanning protein tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity;
Cellular component	endosome; membrane; extrinsic component of cytoplasmic side of plasma membrane; adherens junction; plasma membrane; cell junction; Grb2-EGFR complex; clathrin-coated pit; cytoplasmic vesicle membrane; cytoplasmic vesicle; nucleus; clathrin-coated vesicle; cytoplasm; perinuclear region of cytoplasm; cytoophidium;
Biological process	cell differentiation; endocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; small GTPase mediated signal transduction; protein phosphorylation; cell surface receptor signaling pathway; regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; regulation of clathrin-dependent endocytosis; innate immune response; cell migration; negative regulation of GTPase activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10188
	51789
	ENSG00000061938
	ENSMUSG00000022791
	Q07912
	O54967
NM_001010938; NM_001308046; NM_005781; NM_001382271; NM_001382272;
	NM_001382273; NM_001382274; NM_001382275
	NM_001110147; NM_001289443; NM_016788; NM_001347185
	NP_001010938; NP_001294975; NP_005772
	NP_001103617; NP_001276372; NP_001334114; NP_058068
	Wikidata
View/Edit Human	View/Edit Mouse

Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.