Troponin C type 1

TNNC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AP4, 1IH0, 1J1D, 1J1E, 1LXF, 1MXL, 1OZS, 1SPY, 1WRK, 1WRL, 2JT0, 2JT3, 2JT8, 2JTZ, 2JXL, 2KDH, 2KFX, 2KGB, 2KRD, 2L1R, 2L98, 2MKP, 2MLE, 2MLF, 2MZP, 3RV5, 3SD6, 3SWB, 4GJE, 4GJF, 4GJG, 2N79, 4Y99
Identifiers
Aliases	TNNC1, CMD1Z, CMH13, TN-C, TNC, TNNC, Troponin C type 1, troponin C1, slow skeletal and cardiac type
External IDs	OMIM: 191040; MGI: 98779; HomoloGene: 55728; GeneCards: TNNC1; OMA:TNNC1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,454,041 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,933,686 bp
RNA expression pattern
	Top expressed in
	glutes; ; right ventricle; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; myocardium of left ventricle; ; vastus lateralis muscle; ; apex of heart; ; muscle of thigh;
	Top expressed in
	interventricular septum; ; cardiac muscles; ; soleus muscle; ; myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; atrium; ; ankle; ; atrioventricular valve; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein homodimerization activity; troponin T binding; metal ion binding; calcium-dependent protein binding; protein binding; troponin I binding; actin filament binding;
Cellular component	cytosol; troponin complex; contractile fiber; cardiac Troponin complex;
Biological process	regulation of muscle contraction; transition between fast and slow fiber; diaphragm contraction; response to metal ion; ventricular cardiac muscle tissue morphogenesis; muscle filament sliding; regulation of muscle filament sliding speed; regulation of ATP-dependent activity; skeletal muscle contraction; cardiac muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7134
	21924
	ENSG00000114854
	ENSMUSG00000091898
	P63316
	P19123
	NM_003280
	NM_009393
	NP_003271
	NP_033419
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated muscle (cardiac, fast-twitch skeletal, or slow-twitch skeletal) and is responsible for binding calcium to activate muscle contraction. Troponin C is encoded by the TNNC1 gene in humans for both cardiac and slow skeletal muscle.