TNNI3

TNNI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J1D, 1J1E, 1LXF, 1MXL, 1OZS, 2KGB, 2KRD, 2L1R, 2MZP, 4Y99
Identifiers
Aliases	TNNI3, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI, troponin I3, cardiac type
External IDs	OMIM: 191044; MGI: 98783; HomoloGene: 309; GeneCards: TNNI3; OMA:TNNI3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,157,773 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,527,228 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; myocardium of left ventricle; ; right auricle of heart; ; right ventricle; ; cardiac muscle tissue of right atrium; ; vena cava; ; right uterine tube; ; gonad; ; testicle; ; muscle of thigh;
	Top expressed in
	myocardium; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; interventricular septum; ; atrium; ; atrioventricular valve; ; aortic valve; ; endocardial cushion; ; epithelium of stomach; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase binding; protein binding; troponin T binding; calcium-dependent protein binding; calcium channel inhibitor activity; protein domain specific binding; troponin C binding; actin binding; metal ion binding; actin filament binding;
Cellular component	troponin complex; sarcomere; cytosol; cytoplasm; contractile fiber; myofibril; cardiac myofibril; cardiac Troponin complex;
Biological process	ventricular cardiac muscle tissue morphogenesis; negative regulation of ATP-dependent activity; vasculogenesis; cardiac muscle contraction; regulation of muscle contraction; heart development; muscle filament sliding; heart contraction; regulation of smooth muscle contraction; striated muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; cellular calcium ion homeostasis; skeletal muscle contraction; regulation of cardiac muscle contraction by calcium ion signaling; muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7137
	21954
	ENSG00000129991
	ENSMUSG00000035458
	P19429; Q6FGX2
	P48787
	NM_000363
	NM_009406
	NP_000354; NP_000354.4
	NP_033432
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene. It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex.

The TNNI3 gene encoding cardiac troponin I (cTnI) is located at 19q13.4 in the human chromosomal genome. Human cTnI is a 24 kDa protein consisting of 210 amino acids with isoelectric point (pI) of 9.87. cTnI is exclusively expressed in adult cardiac muscle.