TNNT2

TNNT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J1D, 1J1E, 4Y99
Identifiers
Aliases	TNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, troponin T2, cardiac type
External IDs	OMIM: 191045; MGI: 104597; HomoloGene: 68050; GeneCards: TNNT2; OMA:TNNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	201,377,764 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,779,998 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right auricle of heart; ; left ventricle; ; sural nerve; ; right frontal lobe; ; skin of leg; ; Brodmann area 9; ; skin of abdomen; ; anterior cingulate cortex; ; right lung;
	Top expressed in
	atrioventricular valve; ; atrium; ; myocardium of ventricle; ; left ventricle; ; aortic valve; ; cardiac muscles; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; ATPase activity; protein binding; actin binding; tropomyosin binding; troponin C binding; troponin I binding; calcium ion binding; calcium-dependent ATPase activity;
Cellular component	cytosol; troponin complex; sarcomere; striated muscle thin filament; myofibril; cardiac myofibril; cardiac Troponin complex;
Biological process	regulation of muscle contraction; muscle contraction; regulation of heart contraction; positive regulation of ATP-dependent activity; negative regulation of ATP-dependent activity; response to calcium ion; ventricular cardiac muscle tissue morphogenesis; actin crosslink formation; muscle filament sliding; regulation of muscle filament sliding speed; cardiac muscle contraction; protein heterooligomerization; skeletal muscle contraction; sarcomere organization;
	Sources:Amigo / QuickGO
Orthologs
	7139
	21956
	ENSG00000118194
	ENSMUSG00000026414
	P45379
	P50752
NM_000364; NM_001001430; NM_001001431; NM_001001432; NM_001276345;
	NM_001276346; NM_001276347
NM_001130174; NM_001130175; NM_001130176; NM_001130177; NM_001130178;
	NM_001130179; NM_001130180; NM_001130181; NM_011619
NP_000355; NP_001001430; NP_001001431; NP_001001432; NP_001263274;
	NP_001263275; NP_001263276
NP_001123646; NP_001123647; NP_001123648; NP_001123649; NP_001123650;
	NP_001123651; NP_001123652; NP_001123653; NP_035749
	Wikidata
View/Edit Human	View/Edit Mouse

Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.

The TNNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). Human cTnT is an ~36-kDa protein consisting of 297 amino acids including the first methionine with an isoelectric point (pI) of 4.88. It is the tropomyosin- binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells. TNNT2 gene is expressed in vertebrate cardiac muscles and embryonic skeletal muscles.