TNRC6A

TNRC6A
Identifiers
Aliases	TNRC6A, CAGH26, GW1, GW182, TNRC6, trinucleotide repeat containing 6A, FAME6, trinucleotide repeat containing adaptor 6A
External IDs	OMIM: 610739; MGI: 2385292; HomoloGene: 41399; GeneCards: TNRC6A; OMA:TNRC6A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	24,827,632 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	122,794,519 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; sural nerve; ; Cerebellum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; pituitary gland; ; endometrium; ; gastric mucosa; ; left ovary;
	Top expressed in
	ciliary body; ; Gonadal ridge; ; retinal pigment epithelium; ; iris; ; primitive streak; ; arcuate nucleus; ; median eminence; ; lacrimal gland; ; ventromedial nucleus; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; P-body; nucleoplasm;
Biological process	RNA interference; gene silencing by miRNA; regulation of translation; miRNA-mediated gene silencing by inhibition of translation; Wnt signaling pathway, calcium modulating pathway; gene silencing; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; cellular response to starvation; positive regulation of gene expression; negative regulation of gene expression; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;
	Sources:Amigo / QuickGO
Orthologs
	27327
	233833
	ENSG00000090905; ENSG00000288130
	ENSMUSG00000052707
	Q8NDV7
	Q3UHK8
	NM_014494; NM_001330520; NM_001351850
	NM_144925
	NP_001317449; NP_055309; NP_001338779
	NP_659174
	Wikidata
View/Edit Human	View/Edit Mouse

Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6A gene.

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.