TNS1

TNS1
Identifiers
Aliases	TNS1, MST091, MST122, MST127, MSTP122, MSTP127, MXRA6, PPP1R155, TNS, MSTP091, tensin 1
External IDs	OMIM: 600076; MGI: 104552; HomoloGene: 11219; GeneCards: TNS1; OMA:TNS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,002,995 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,163,608 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; urethra; ; tail of epididymis; ; lower lobe of lung; ; seminal vesicula; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; right coronary artery; ; popliteal artery; ; tibial arteries;
	Top expressed in
	ascending aorta; ; aortic valve; ; interventricular septum; ; right lung; ; left lung; ; right lung lobe; ; left lung lobe; ; muscle of thigh; ; tunica media of zone of aorta; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; RNA binding;
Cellular component	cytoplasm; cell-substrate junction; cell surface; cell junction; cytoskeleton; focal adhesion;
Biological process	cell-substrate junction assembly; fibroblast migration;
	Sources:Amigo / QuickGO
Orthologs
	7145
	21961
	ENSG00000079308
	ENSMUSG00000055322
	Q9HBL0; Q0VG54
	n/a
	NM_001308022; NM_001308023; NM_022648
	NM_001289895; NM_027884; NM_177169
	NP_001294951; NP_001294952; NP_072174; NP_001294951.1; NP_001294952.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.