TOM1

TOM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ELK, 1WRD, 2N2N
Identifiers
Aliases	TOM1, target of myb1 membrane trafficking protein, IMD85
External IDs	OMIM: 604700; MGI: 1338026; HomoloGene: 88453; GeneCards: TOM1; OMA:TOM1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,347,992 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,796,749 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; skin of leg; ; skin of abdomen; ; monocyte; ; apex of heart; ; stromal cell of endometrium; ; minor salivary glands; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	lens; ; muscle tissue; ; skeletal muscle tissue; ; granulocyte; ; lip; ; muscle of thigh; ; yolk sac; ; quadriceps femoris muscle; ; heart; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding; protein binding;
Cellular component	cytosol; endosome; early endosome; extracellular exosome; intracellular anatomical structure; cytoplasm; membrane; plasma membrane; azurophil granule membrane; specific granule membrane;
Biological process	intracellular protein transport; endocytosis; endosomal transport; protein transport; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	10043
	21968
	ENSG00000100284
	ENSMUSG00000042870
	O60784
	O88746
	NM_001135729; NM_001135730; NM_001135732; NM_005488
	NM_001136259; NM_011622
	NP_001129201; NP_001129202; NP_001129204; NP_005479
	NP_001129731; NP_035752
	Wikidata
View/Edit Human	View/Edit Mouse

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.