TOP1

TOP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8
Identifiers
Aliases	TOP1, TOPI, topoisomerase (DNA) I, DNA topoisomerase I
External IDs	OMIM: 126420; MGI: 98788; HomoloGene: 2467; GeneCards: TOP1; OMA:TOP1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	41,124,487 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	160,564,684 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; pericardium; ; pylorus; ; vena cava; ; pancreatic ductal cell; ; superior surface of tongue; ; monocyte;
	Top expressed in
	Ileal epithelium; ; zygote; ; secondary oocyte; ; maxillary prominence; ; mandibular prominence; ; tail of embryo; ; human fetus; ; genital tubercle; ; ventricular zone; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA topoisomerase type I (single strand cut, ATP-independent) activity; chromatin binding; isomerase activity; DNA topoisomerase activity; core promoter sequence-specific DNA binding; protein binding; RNA binding; DNA binding; double-stranded DNA binding; single-stranded DNA binding; protein serine/threonine kinase activity; ATP binding; protein domain specific binding; supercoiled DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; perikaryon; P-body; replication fork protection complex; chromosome; nuclear chromosome; nucleus; fibrillar center; nucleoplasm; nucleolus; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; protein-DNA complex;
Biological process	chromatin remodeling; embryonic cleavage; programmed cell death; phosphorylation; rhythmic process; chromosome segregation; protein sumoylation; circadian regulation of gene expression; DNA replication; circadian rhythm; viral process; DNA topological change; peptidyl-serine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	7150
	21969
	ENSG00000198900
	ENSMUSG00000070544
	P11387
	Q04750
	NM_003286
	NM_009408
	NP_003277
	NP_033434
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.