TOP2A

TOP2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZXM, 1ZXN, 4FM9, 4R1F
Identifiers
Aliases	TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha
External IDs	OMIM: 126430; MGI: 98790; HomoloGene: 830; GeneCards: TOP2A; OMA:TOP2A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,417,896 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,915,015 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; right testis; ; left testis; ; bone marrow; ; trabecular bone; ; gonad; ; bone marrow cells; ; testicle;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; fetal liver hematopoietic progenitor cell; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; epiblast; ; tibiofemoral joint; ; somite;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP-dependent activity, acting on DNA; protein homodimerization activity; histone deacetylase binding; chromatin binding; isomerase activity; metal ion binding; DNA topoisomerase activity; protein C-terminus binding; ubiquitin binding; protein binding; protein heterodimerization activity; enzyme binding; ATP binding; protein kinase C binding; magnesium ion binding; DNA binding, bending; RNA binding; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;
Cellular component	cytoplasm; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; nucleoplasm; nuclear chromosome; nucleolus; centriole; condensed chromosome; nucleus; viral integration complex; protein-containing complex; ribonucleoprotein complex;
Biological process	resolution of meiotic recombination intermediates; apoptotic chromosome condensation; embryonic cleavage; rhythmic process; chromosome segregation; DNA metabolic process; protein sumoylation; cellular response to DNA damage stimulus; DNA ligation; chromosome condensation; regulation of circadian rhythm; hematopoietic progenitor cell differentiation; positive regulation of apoptotic process; mitotic DNA integrity checkpoint signaling; positive regulation of viral genome replication; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; sister chromatid segregation; positive regulation of transcription by RNA polymerase II; DNA topological change; negative regulation of DNA duplex unwinding; female meiotic nuclear division;
	Sources:Amigo / QuickGO
Orthologs
	7153
	21973
	ENSG00000131747
	ENSMUSG00000020914
	P11388
	Q01320
	NM_001067
	NM_011623
	NP_001058
	NP_035753
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.

Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several chemotherapy agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.